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Because patients prescribed digoxin are frequently elderly, have multiple underlying comorbidities (e. Amitiza is also approved for the treatment of irritable bowel syndrome with constipation (IBS-C) in women 18 years of age and older. Danazol: (Major) Danazol is a CYP3A4 inhibitor and can decrease the hepatic metabolism of some drugs, such as ergot alkaloids, and lead to ergot toxicity https://dansk-apotek.com/. The anticholinergic effects of atropine are generally insignificant when used in normal doses.